Abstract
A synthetic tetrasaccharide structurally related to blood groups and selectin ligands inhibited division of astrocytes, gliomas, and neuroblastomas at micromolar concentrations. The compound was cytostatic for primary astrocytes in culture, but cytotoxic for fast proliferating cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Blood Group Antigens / metabolism*
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Carbohydrate Sequence
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Cell Division
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Molecular Sequence Data
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Neurons / cytology*
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Oligosaccharides / metabolism*
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Rats
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Structure-Activity Relationship
Substances
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Blood Group Antigens
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Oligosaccharides