Antimelanomal activity of the copper(II) complexes of 1-substituted 5-amino-imidazole ligands against B16F10 mouse melanoma cells

Uday Sandbhor; Pallavi Kulkarni; Subhash Padhye; Gopal Kundu; Grahame Mackenzie; Robin Pritchard

doi:10.1016/j.bmcl.2004.03.041

Antimelanomal activity of the copper(II) complexes of 1-substituted 5-amino-imidazole ligands against B16F10 mouse melanoma cells

Bioorg Med Chem Lett. 2004 Jun 7;14(11):2877-82. doi: 10.1016/j.bmcl.2004.03.041.

Authors

Uday Sandbhor¹, Pallavi Kulkarni, Subhash Padhye, Gopal Kundu, Grahame Mackenzie, Robin Pritchard

Affiliation

¹ Department of Chemistry, University of Pune, Pune 411007, India. [email protected]

PMID: 15125951
DOI: 10.1016/j.bmcl.2004.03.041

Abstract

The copper complexes of 5-amino-imidazole ligands were prepared and characterized by various spectroscopic techniques. The ligand geometry around the copper(II) centre is square pyramidal based on N2O2 donor atoms and a coordinated water molecule at the apex. Single crystal X-ray structures were determined for both ligands. Ligands and copper complexes exhibited dose-dependent antiproliferative effects on the growth of B16F10 melanoma cells line but lower IC50 values were observed for the copper complexes.

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Copper
Dose-Response Relationship, Drug
Imidazoles / chemical synthesis
Imidazoles / chemistry
Imidazoles / pharmacology
Inhibitory Concentration 50
Ligands
Melanoma / drug therapy*
Melanoma / pathology
Mice
Molecular Structure
Organometallic Compounds / chemical synthesis
Organometallic Compounds / chemistry
Organometallic Compounds / pharmacology*
Spectrum Analysis
Structure-Activity Relationship

Substances

Antineoplastic Agents
Imidazoles
Ligands
Organometallic Compounds
Copper