The distribution of serotonin transporter immunoreactivity in hippocampal formation in monkeys and rats

Toshimi Owashi; Shuji Iritani; Kazuhiro Niizato; Kenji Ikeda; Kunitoshi Kamijima

doi:10.1016/j.brainres.2004.03.013

The distribution of serotonin transporter immunoreactivity in hippocampal formation in monkeys and rats

Brain Res. 2004 Jun 4;1010(1-2):166-8. doi: 10.1016/j.brainres.2004.03.013.

Authors

Toshimi Owashi¹, Shuji Iritani, Kazuhiro Niizato, Kenji Ikeda, Kunitoshi Kamijima

Affiliation

¹ Department of Psychiatry, Showa University School of Medicine, 1-5-8, Hatanodai, Shinagawa, Tokyo 142-8666, Japan. [email protected]

PMID: 15126130
DOI: 10.1016/j.brainres.2004.03.013

Abstract

To elucidate the anatomical distribution of the serotonergic neurotransmitter system, we identified serotonin transporter (5-HTT) in the hippocampus of rats and monkeys by immunohistochemistry. A widespread and heterogeneous distribution of 5-HTT-immunoreactive fine fibers was noted in the rat brain. However, in monkeys, punctuate 5-HTT-immunoreactive deposits and fewer fibers were observed. The species difference in 5-HTT immunohistochemical staining pattern may be caused by differences in localization of 5-HTT between species.

Publication types

Comparative Study

MeSH terms

Animals
Carrier Proteins / biosynthesis*
Hippocampus / anatomy & histology
Hippocampus / cytology
Hippocampus / metabolism*
Immunohistochemistry
Macaca
Membrane Glycoproteins / biosynthesis*
Membrane Transport Proteins*
Nerve Fibers / metabolism
Nerve Tissue Proteins / biosynthesis*
Neurons / metabolism*
Rats
Rats, Wistar
Serotonin / metabolism*
Serotonin Plasma Membrane Transport Proteins
Species Specificity

Substances

Carrier Proteins
Membrane Glycoproteins
Membrane Transport Proteins
Nerve Tissue Proteins
Serotonin Plasma Membrane Transport Proteins
Slc6a4 protein, rat
Serotonin