Progressive beta cell failure in type 2 diabetes mellitus of youth

Neslihan Gungor; Silva Arslanian

doi:10.1016/j.jpeds.2003.12.045

Progressive beta cell failure in type 2 diabetes mellitus of youth

J Pediatr. 2004 May;144(5):656-9. doi: 10.1016/j.jpeds.2003.12.045.

Authors

Neslihan Gungor¹, Silva Arslanian

Affiliation

¹ Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

PMID: 15127006
DOI: 10.1016/j.jpeds.2003.12.045

Abstract

The pathophysiology of type 2 diabetes mellitus (T2DM) involves insulin resistance and insulin deficiency. We report the progression in insulin sensitivity and secretion over a 6-year period in an adolescent with T2DM. This report further demonstrates that the earliest abnormality in youth T2DM is insulin resistance followed by progressive beta-cell failure.

Publication types

Case Reports
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Child
Diabetes Mellitus, Type 2 / physiopathology*
Disease Progression
Female
Humans
Insulin Resistance
Islets of Langerhans / physiopathology*

Abstract

Publication types

MeSH terms

Grants and funding