Osteoporosis in MCHR1-deficient mice

Mohammad Bohlooly-Y; Margit Mahlapuu; Harriet Andersén; Annika Astrand; Stephan Hjorth; Lennart Svensson; Jan Törnell; Michael R Snaith; David G Morgan; Claes Ohlsson

doi:10.1016/j.bbrc.2004.04.122

Osteoporosis in MCHR1-deficient mice

Biochem Biophys Res Commun. 2004 Jun 11;318(4):964-9. doi: 10.1016/j.bbrc.2004.04.122.

Authors

Mohammad Bohlooly-Y¹, Margit Mahlapuu, Harriet Andersén, Annika Astrand, Stephan Hjorth, Lennart Svensson, Jan Törnell, Michael R Snaith, David G Morgan, Claes Ohlsson

Affiliation

¹ AstraZeneca Transgenics and Comparative Genomics Centre, AstraZeneca R&D, Mölndal, Sweden.

PMID: 15147966
DOI: 10.1016/j.bbrc.2004.04.122

Abstract

It is well recognized that the hypothalamus is of central importance in the regulation of food intake and fat mass. Recent studies indicate that it also plays an important role in the regulation of bone mass. Melanin concentrating hormone (MCH) is highly expressed in the hypothalamus and has been implicated in regulation of energy homeostasis. We developed MCHR1 inactivated mice to evaluate the physiological role of this receptor. Interestingly, the MCHR1(-/-) mice have osteoporosis, caused by a reduction in the cortical bone mass, while the amount of trabecular bone is unaffected. The reduction in cortical bone mass is due to decreased cortical thickness. Serum levels of c-telopeptide, a marker of bone resorption, are increased in MCHR1(-/-) mice, indicating that the MCHR1(-/-) mice have a high bone turnover osteoporosis. In conclusion, the MCHR1(-/-) mice have osteoporosis, indicating that MCHR1-signalling is involved in a tonic stimulation of bone mass.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Absorptiometry, Photon
Animals
Biomarkers / blood
Bone Density / physiology
Bone Resorption / blood
Collagen / blood
Collagen Type I
Female
Femur / chemistry
Femur / diagnostic imaging
Femur / pathology
Gene Components
Gene Expression
Hypothalamic Hormones / metabolism
Male
Melanins / metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Osteocalcin / blood
Osteoporosis / blood
Osteoporosis / genetics
Osteoporosis / metabolism*
Peptides / blood
Pituitary Hormones / metabolism
RNA, Messenger / biosynthesis
Receptors, Pituitary Hormone / deficiency*
Receptors, Pituitary Hormone / genetics
Receptors, Pituitary Hormone / physiology*
Tissue Distribution

Substances

Biomarkers
Collagen Type I
Hypothalamic Hormones
Melanins
Peptides
Pituitary Hormones
RNA, Messenger
Receptors, Pituitary Hormone
collagen type I trimeric cross-linked peptide
melanin-concentrating hormone receptor
Osteocalcin
melanin-concentrating hormone
Collagen