Stay close to your sister

Mol Cell. 2004 May 21;14(4):418-20. doi: 10.1016/s1097-2765(04)00266-7.

Abstract

Yeast Sir2 protein regulates chromatin structure and suppresses recombination at the multiple tandem rDNA array. In the current issue of Cell, Kobayashi and colleagues reinvestigate rDNA dynamics in sir2 strains and find that Sir2 is necessary to recruit cohesins to the array, which influences the nature of rDNA recombination events.

Publication types

  • Review

MeSH terms

  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • Chromosome Segregation / genetics
  • Cohesins
  • DNA, Ribosomal / genetics*
  • Fungal Proteins
  • Histone Deacetylases / genetics*
  • Mitosis / genetics
  • Mutation / genetics
  • Nuclear Proteins / genetics*
  • Recombination, Genetic / genetics*
  • Sequence Homology
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae / genetics*
  • Sirtuin 2
  • Sirtuins / genetics*
  • Yeasts / genetics*
  • Yeasts / metabolism

Substances

  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • DNA, Ribosomal
  • Fungal Proteins
  • Nuclear Proteins
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae
  • SIR2 protein, S cerevisiae
  • Sirtuin 2
  • Sirtuins
  • Histone Deacetylases