A novel mixed-ligand antimycobacterial dimeric copper complex of ciprofloxacin and phenanthroline

Dilip Kumar Saha; Uday Sandbhor; K Shirisha; Subhash Padhye; Dileep Deobagkar; Christopher E Anson; Annie K Powell

doi:10.1016/j.bmcl.2004.04.043

A novel mixed-ligand antimycobacterial dimeric copper complex of ciprofloxacin and phenanthroline

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3027-32. doi: 10.1016/j.bmcl.2004.04.043.

Authors

Dilip Kumar Saha¹, Uday Sandbhor, K Shirisha, Subhash Padhye, Dileep Deobagkar, Christopher E Anson, Annie K Powell

Affiliation

¹ Department of Chemistry, University of Pune, Pune 411007, India.

PMID: 15149638
DOI: 10.1016/j.bmcl.2004.04.043

Abstract

A novel mixed-ligand Cu(II) complex of ciprofloxacin (cfH) and phenanthroline, is found to crystallize as a dimeric moiety containing monocationic and dicationic species. Two such dimeric moieties are found in the same unit cell leading to a dicationic cluster. The higher negative redox potential for this cluster dampens its antimycobacterial activity against M. smegmatis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology
Ciprofloxacin / chemistry*
Ciprofloxacin / pharmacology
Copper / chemistry*
Copper / pharmacology
Ligands
Mycobacterium smegmatis / drug effects
Mycobacterium smegmatis / growth & development
Phenanthrolines / chemistry*
Phenanthrolines / pharmacology

Substances

Anti-Bacterial Agents
Ligands
Phenanthrolines
Ciprofloxacin
Copper