Identification and optimization of novel partial agonists of neuromedin B receptor using parallel synthesis

Stephen J Shuttleworth; Mike E Lizarzaburu; Anne Chai; Peter Coward

doi:10.1016/j.bmcl.2004.04.045

Identification and optimization of novel partial agonists of neuromedin B receptor using parallel synthesis

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3037-42. doi: 10.1016/j.bmcl.2004.04.045.

Authors

Stephen J Shuttleworth¹, Mike E Lizarzaburu, Anne Chai, Peter Coward

Affiliation

¹ Department of Chemistry, Tularik Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.

PMID: 15149640
DOI: 10.1016/j.bmcl.2004.04.045

Abstract

The design and parallel synthesis of potent, small molecule partial agonists of Neuromedin B receptor based on the 3-amino-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid amide core is described.

MeSH terms

Chemistry, Pharmaceutical / methods*
Dose-Response Relationship, Drug
HeLa Cells
Humans
Indoles / chemistry*
Indoles / pharmacology
Receptors, Bombesin / agonists*
Structure-Activity Relationship

Substances

Indoles
PD 165929
Receptors, Bombesin