Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives

Teija Parkkari; Juha R Savinainen; Anu L Rauhala; Tiina L Tolonen; Tapio Nevalainen; Jarmo T Laitinen; Jukka Gynther; Tomi Järvinen

doi:10.1016/j.bmcl.2004.03.093

Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3231-4. doi: 10.1016/j.bmcl.2004.03.093.

Authors

Teija Parkkari¹, Juha R Savinainen, Anu L Rauhala, Tiina L Tolonen, Tapio Nevalainen, Jarmo T Laitinen, Jukka Gynther, Tomi Järvinen

Affiliation

¹ Department of Pharmaceutical Chemistry, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland. [email protected]

PMID: 15149681
DOI: 10.1016/j.bmcl.2004.03.093

Abstract

Novel derivatives of arachidonyl alcohol were synthesized and evaluated for their CB1 receptor activity by [(35)S]GTP(gamma)S assay using rat cerebellar membranes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alcohols / chemical synthesis*
Alcohols / metabolism
Animals
Arachidonic Acids / chemical synthesis*
Arachidonic Acids / metabolism
Dose-Response Relationship, Drug
Male
Rats
Rats, Wistar
Receptor, Cannabinoid, CB1 / metabolism*

Substances

Alcohols
Arachidonic Acids
Receptor, Cannabinoid, CB1