Abstract
Rapid, saturable, specific and stereoselective binding of L-dopa to crude membranes and purified nuclei from rodent amelanotic melanoma cells is reported. Cross-linking of [3H]dopa to melanoma cell surface emphasized proteins of approx. 55, 30, 25 and less than 20 kDa. It is suggested that these binding sites may regulate melanocyte activity.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Binding Sites
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Carrier Proteins / metabolism
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Cell Membrane / metabolism*
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Cell Nucleus / metabolism*
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Cricetinae
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Levodopa / metabolism*
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Melanoma / metabolism*
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Membrane Proteins / metabolism
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Mice
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Tumor Cells, Cultured
Substances
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Carrier Proteins
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Membrane Proteins
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Levodopa