Abstract
We report that the amiloride analogues 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amiloride / analogs & derivatives*
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Amiloride / pharmacology*
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Anti-HIV Agents / pharmacology*
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Cell Division / drug effects
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Cell Survival / drug effects
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Cells, Cultured
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DNA, Viral / biosynthesis
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DNA, Viral / genetics
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HIV Core Protein p24 / biosynthesis
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HIV Core Protein p24 / genetics
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HIV-1 / drug effects*
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HIV-1 / growth & development
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Human Immunodeficiency Virus Proteins
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Humans
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Macrophages / drug effects
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Macrophages / virology*
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RNA, Viral / biosynthesis
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RNA, Viral / genetics
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Viral Regulatory and Accessory Proteins / biosynthesis
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Virus Replication / drug effects*
Substances
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Anti-HIV Agents
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DNA, Viral
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HIV Core Protein p24
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Human Immunodeficiency Virus Proteins
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RNA, Viral
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Viral Regulatory and Accessory Proteins
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vpu protein, Human immunodeficiency virus 1
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5-(N,N-hexamethylene)amiloride
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5-dimethylamiloride
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Amiloride