Abstract
This report describes a 49-year-old woman with a well-circumscribed nodule of liposarcoma. The patient noticed a soft, slowly growing mass at the right sural region. Both axial computed tomography and magnetic resonance imaging revealed a soft tissue tumor consisting of nonfatty lesion measuring 5 x 3 x 3 cm circumscribed by a 1-cm thickened fatty area. Histologically, the tumor was made of 2 distinct components: the inner component of the tumor was a classic myxoid liposarcoma with numerous lipoblasts; the outer component was a lipoma-like lesion consisting of mature adipocytes without atypical nuclei. Immunohistochemically, MDM2 overexpression was observed and p53 immunophenotype was negative in both components. Molecular analysis revealed that type 1 TLS/ CHOP fusion gene transcript, characteristic of myxoid/round cell liposarcoma, was detected in both areas.
MeSH terms
-
Adipocytes / metabolism
-
Adipocytes / pathology*
-
CCAAT-Enhancer-Binding Proteins / genetics*
-
Female
-
Humans
-
Immunohistochemistry
-
Ki-67 Antigen / metabolism
-
Leg / pathology
-
Liposarcoma, Myxoid / genetics*
-
Liposarcoma, Myxoid / metabolism
-
Liposarcoma, Myxoid / pathology*
-
Middle Aged
-
Nuclear Proteins / metabolism
-
Oncogene Proteins, Fusion / genetics*
-
Proto-Oncogene Proteins / metabolism
-
Proto-Oncogene Proteins c-mdm2
-
RNA-Binding Protein FUS / genetics*
-
Reverse Transcriptase Polymerase Chain Reaction
-
Soft Tissue Neoplasms / genetics*
-
Soft Tissue Neoplasms / metabolism
-
Soft Tissue Neoplasms / pathology*
-
Tomography, X-Ray Computed
-
Transcription Factor CHOP
-
Tumor Suppressor Protein p53 / metabolism
Substances
-
CCAAT-Enhancer-Binding Proteins
-
Ki-67 Antigen
-
Nuclear Proteins
-
Oncogene Proteins, Fusion
-
Proto-Oncogene Proteins
-
RNA-Binding Protein FUS
-
TLS-CHOP fusion protein, human
-
Tumor Suppressor Protein p53
-
Transcription Factor CHOP
-
MDM2 protein, human
-
Proto-Oncogene Proteins c-mdm2