Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types

Dev Biol. 2004 Jun 15;270(2):443-54. doi: 10.1016/j.ydbio.2004.03.013.

Abstract

Mice deficient for the transcription factor neurogenin 3 (ngn3) fail to develop endocrine cells in the intestine and pancreas and show partial endocrine differentiation in the stomach. We expressed Cre recombinase under control of a ngn3 BAC to achieve high fidelity cell lineage tracing in vivo to determine whether endocrine cells in these organs differentiate from NGN3+ precursor cells. Our results indicate that all small intestinal enteroendocrine cells arise from ngn3-expressing cells and confirm that NGN3+ cells give rise to all pancreatic endocrine cells as noted previously. By examining mice at a developmental stage when all of the cell types in the stomach have differentiated, we have delineated region-associated differences in endocrine differentiation. A much smaller fraction of endocrine cells populating the acid-producing region of the stomach is derived from NGN3+ precursor in contrast to the antral-pyloric region. Unexpectedly, ngn3 is expressed in cells that adopt non-endocrine cell fates including significant fractions of goblet and Paneth cells in the intestine and a small number of duct and acinar cells in the pancreas. Rarely, ngn3 was expressed in pluripotent cells in intestinal crypts with resultant labeling of an entire crypt-villus unit. Thus, ngn3 expression occurs in mixed populations of immature cells that are not irreversibly committed to endocrine differentiation.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors
  • Cell Differentiation / physiology*
  • Cell Lineage / physiology
  • Chromosomes, Artificial, Bacterial
  • DNA Primers
  • Enteroendocrine Cells / physiology
  • Gastrointestinal Tract / cytology
  • Gastrointestinal Tract / metabolism*
  • Gene Expression Regulation, Developmental*
  • Histological Techniques
  • Immunohistochemistry
  • Integrases / genetics
  • Integrases / metabolism
  • Mice / embryology*
  • Mice, Transgenic
  • Nerve Tissue Proteins / metabolism*
  • Stem Cells / metabolism*
  • beta-Galactosidase

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • DNA Primers
  • Nerve Tissue Proteins
  • Neurog3 protein, mouse
  • Cre recombinase
  • Integrases
  • beta-Galactosidase