Abstract
The authors used a liquid-phase radiobinding assay to measure serum anti-myelin oligodendrocyte protein (MOG) immunoglobulin (Ig) G in 87 patients with multiple sclerosis (MS), in 12 patients with encephalomyelitis, and in 47 healthy subjects. Anti-MOG IgM was determined in samples obtained at onset from 40 of 87 patients with MS and in control subjects. The frequency of positive samples with low titers of anti-MOG IgG (< or =5.7%) and IgM (< or =8.3%) was similar in all the groups and subgroups. Binding competition experiments showed that these antibodies had low affinity. Anti-MOG antibodies are not disease specific.
MeSH terms
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Adolescent
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Adult
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Animals
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Autoantibodies / blood
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Autoantibodies / immunology*
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Autoantigens / immunology*
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Demyelinating Diseases / blood
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Demyelinating Diseases / immunology
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Encephalomyelitis / blood
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Encephalomyelitis / immunology
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Encephalomyelitis, Autoimmune, Experimental / blood
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Encephalomyelitis, Autoimmune, Experimental / immunology
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Female
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Humans
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Immunoglobulin G / blood
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Immunoglobulin G / immunology*
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Immunoglobulin M / blood
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Immunoglobulin M / immunology*
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Male
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Mice
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Mice, Inbred C57BL
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Middle Aged
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Multiple Sclerosis, Chronic Progressive / blood
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Multiple Sclerosis, Chronic Progressive / immunology*
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Multiple Sclerosis, Relapsing-Remitting / blood
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Multiple Sclerosis, Relapsing-Remitting / immunology*
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Myelin Proteins
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Myelin-Associated Glycoprotein / immunology*
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Myelin-Oligodendrocyte Glycoprotein
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Rabbits
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Radioligand Assay
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Subacute Sclerosing Panencephalitis / blood
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Subacute Sclerosing Panencephalitis / immunology
Substances
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Autoantibodies
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Autoantigens
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Immunoglobulin G
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Immunoglobulin M
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MOG protein, human
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Mog protein, mouse
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Myelin Proteins
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Myelin-Associated Glycoprotein
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Myelin-Oligodendrocyte Glycoprotein