Comparison of frequency of interferon-gamma-positive CD4+ T cells before and after percutaneous coronary intervention and the effect of statin therapy in patients with stable angina pectoris

Tomoko Tanaka; Hirofumi Soejima; Nobutaka Hirai; Tomohiro Sakamoto; Michihiro Yoshimura; Ichiro Kajiwara; Yuji Miyao; Kazuteru Fujimoto; Hiroo Miyagi; Atsushi Irie; Yasuharu Nishimura; Hisao Ogawa

doi:10.1016/j.amjcard.2004.02.070

Comparison of frequency of interferon-gamma-positive CD4+ T cells before and after percutaneous coronary intervention and the effect of statin therapy in patients with stable angina pectoris

Am J Cardiol. 2004 Jun 15;93(12):1547-9. doi: 10.1016/j.amjcard.2004.02.070.

Authors

Tomoko Tanaka¹, Hirofumi Soejima, Nobutaka Hirai, Tomohiro Sakamoto, Michihiro Yoshimura, Ichiro Kajiwara, Yuji Miyao, Kazuteru Fujimoto, Hiroo Miyagi, Atsushi Irie, Yasuharu Nishimura, Hisao Ogawa

Affiliation

¹ Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Japan.

PMID: 15194033
DOI: 10.1016/j.amjcard.2004.02.070

Abstract

We investigated the effect of statin therapy on T-cell activation in patients who underwent percutaneous coronary intervention by using flow cytometric analysis. The increased frequency of interferon-gamma-positive CD4(+) T cells after percutaneous coronary intervention was significant in the group treated without statins but not in the group treated with statins.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Angina Pectoris / immunology
Angina Pectoris / therapy*
Angioplasty, Balloon, Coronary*
CD4-Positive T-Lymphocytes / metabolism*
Coronary Artery Disease / immunology
Coronary Artery Disease / therapy
Female
Flow Cytometry
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
Interferon-gamma / metabolism*
Lymphocyte Activation / drug effects*
Male

Substances

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Interferon-gamma