Diagnosis and management of pergolide-induced fibrosis

Mov Disord. 2004 Jun;19(6):699-704. doi: 10.1002/mds.20200.

Abstract

We report on 2 patients treated with pergolide, 1 of whom developed pleural fibrosis and the other retroperitoneal fibrosis. In both cases, an extensive diagnostic evaluation and surgical intervention were required to reach a diagnosis. Based on our experience with these patients and a review of cases of pergolide-induced fibrosis in the English-language literature, we propose guidelines for the diagnosis and management of this rare complication.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antiparkinson Agents / adverse effects*
  • Antiparkinson Agents / therapeutic use
  • Biopsy, Needle
  • Bronchi / pathology
  • Female
  • Fibrosis / chemically induced*
  • Fibrosis / diagnosis*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Parkinson Disease / diagnosis*
  • Parkinson Disease / drug therapy*
  • Pergolide / adverse effects*
  • Pergolide / therapeutic use
  • Pleural Diseases / chemically induced*
  • Pleural Diseases / diagnosis*
  • Retroperitoneal Fibrosis / chemically induced*
  • Retroperitoneal Fibrosis / diagnosis*
  • Tomography, X-Ray Computed

Substances

  • Antiparkinson Agents
  • Pergolide