Abstract
Myeloid and plasmacytoid dendritic cells (MDCs, PDCs) play a key role in the initiation of immune responses. In this study, we show a severe reduction of MDCs and PDCs in patients with B lineage acute lymphoblastic leukaemia (B-ALL; P = 0.01 vs. controls). DCs from patients with T lineage ALL (T-ALL) were quantitatively and functionally comparable to healthy donors, as demonstrated by secretion of interleukin (IL)-12p70 and interferon-alpha. In vitro, the circulating CD34(+) fraction of B-ALL cases did not generate either CD1a(+) MDCs or PDCs, suggesting that DC development is probably affected in B-ALL, but not in T-ALL.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Antigens, CD34 / immunology
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Burkitt Lymphoma / immunology
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Case-Control Studies
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Cell Count
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Cells, Cultured
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Child
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Dendritic Cells / immunology*
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Female
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Flow Cytometry
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Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology
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Humans
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Infant
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Interleukin-4 / pharmacology
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Leukemia-Lymphoma, Adult T-Cell / immunology
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Lipopolysaccharide Receptors / immunology
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Male
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Middle Aged
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology*
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Statistics, Nonparametric
Substances
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Antigens, CD34
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Lipopolysaccharide Receptors
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Interleukin-4
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Granulocyte-Macrophage Colony-Stimulating Factor