Increased susceptibility of secretor factor gene Fut2-null mice to experimental vaginal candidiasis

Elizabeth A Hurd; Steven E Domino

doi:10.1128/IAI.72.7.4279-4281.2004

Increased susceptibility of secretor factor gene Fut2-null mice to experimental vaginal candidiasis

Infect Immun. 2004 Jul;72(7):4279-81. doi: 10.1128/IAI.72.7.4279-4281.2004.

Authors

Elizabeth A Hurd¹, Steven E Domino

Affiliation

¹ Department of Obstetrics and Gynecology, 6428 Medical Science I, Box 0617, University of Michigan, Ann Arbor, MI 48109-0617, USA.

Abstract

Fut2-LacZ-null mice, which are a model of the human ABO and Lewis nonsecretor group, display increased susceptibility to experimental yeast vaginitis, indicating a role for alpha(1,2)fucosylated cervical glycans in mucosal defense. However, the lack of significant effect of competitive inhibition by exogenous neoglycoproteins in this study emphasizes the complexity of Candida-epithelial cell adhesion events.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Candidiasis, Vulvovaginal / enzymology*
Female
Fucosyltransferases / deficiency
Fucosyltransferases / genetics*
Galactoside 2-alpha-L-fucosyltransferase
Genes, Reporter
Genetic Predisposition to Disease*
Glycoproteins / antagonists & inhibitors
Mice
Vagina / microbiology*

Substances

Glycoproteins
Fucosyltransferases