Clinical pharmacology of clemastine in healthy dogs

Vet Dermatol. 2004 Jun;15(3):152-8. doi: 10.1111/j.1365-3164.2004.00367.x.

Abstract

The pharmacokinetic properties of clemastine were investigated in six healthy dogs and compared with the effect of the drug recorded as inhibition of wheal formation induced by intradermal injections of histamine. Clemastine clearance was high (median: 2.1 L h(-1) kg(-1)) and the volume of distribution large (13.4 L kg(-1)). The half-life after intravenous administration was 3.8 h and the plasma protein binding level in vitro was 98%. After oral administration, the bioavailability was only 3%. Given intravenously, clemastine (0.1 mg kg(-1)) inhibited wheal formation completely for 7 h, whereas the effect after oral administration (0.5 mg kg(-1)) was minor. The data show that most dosage regimens suggested in the literature for the oral administration of clemastine to dogs are likely to give too low a systemic exposure of the drug to allow effective therapy.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Area Under Curve
  • Biological Availability
  • Clemastine / administration & dosage
  • Clemastine / blood
  • Clemastine / pharmacokinetics*
  • Clemastine / therapeutic use*
  • Cross-Over Studies
  • Dog Diseases / chemically induced
  • Dog Diseases / prevention & control*
  • Dogs / metabolism*
  • Female
  • Histamine
  • Histamine H1 Antagonists / administration & dosage
  • Histamine H1 Antagonists / blood
  • Histamine H1 Antagonists / pharmacokinetics*
  • Histamine H1 Antagonists / therapeutic use*
  • Hypersensitivity / etiology
  • Hypersensitivity / prevention & control
  • Hypersensitivity / veterinary*
  • Injections, Intravenous / veterinary

Substances

  • Histamine H1 Antagonists
  • Histamine
  • Clemastine