Abstract
We evaluated the effect of the combination of micafungin and polymorphonuclear leukocytes (PMN) against hyphae of Candida albicans and Candida dubliniensis. Micafungin enhanced the PMN oxidative burst dose dependently. The combination was synergistic (C. albicans) or additive (C. dubliniensis); when PMN were pretreated with granulocyte-macrophage colony-stimulating factor, the combination was more effective.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Candida / drug effects*
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Echinocandins
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Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology
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Humans
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Hyphae / drug effects*
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In Vitro Techniques
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Lipopeptides
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Lipoproteins / pharmacology*
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Micafungin
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Neutrophils / drug effects
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Neutrophils / metabolism
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Neutrophils / microbiology*
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Peptides, Cyclic / pharmacology*
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Phagocytosis / drug effects*
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Respiratory Burst / drug effects
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Stimulation, Chemical
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Superoxides / metabolism
Substances
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Echinocandins
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Lipopeptides
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Lipoproteins
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Peptides, Cyclic
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Superoxides
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Granulocyte-Macrophage Colony-Stimulating Factor
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Micafungin