6-[18F]Fluoro-A-85380, a new PET tracer for the nicotinic acetylcholine receptor: studies in the human brain and in vivo demonstration of specific binding in white matter

Synapse. 2004 Sep 1;53(3):184-9. doi: 10.1002/syn.20051.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Animals
  • Azetidines / metabolism*
  • Azetidines / pharmacokinetics
  • Brain / diagnostic imaging
  • Brain / drug effects*
  • Brain / metabolism
  • Drug Evaluation
  • Drug Evaluation, Preclinical
  • Female
  • Fluorine Radioisotopes / metabolism*
  • Fluorine Radioisotopes / pharmacokinetics
  • Humans
  • Male
  • Metabolic Clearance Rate
  • Middle Aged
  • Nerve Fibers, Myelinated / drug effects*
  • Nerve Fibers, Myelinated / metabolism
  • Papio
  • Predictive Value of Tests
  • Radioactive Tracers
  • Receptors, Nicotinic / drug effects*
  • Receptors, Nicotinic / metabolism
  • Reproducibility of Results
  • Time Factors
  • Tomography, Emission-Computed / methods

Substances

  • 6-fluoro-3-(2-azetidinylmethoxy)pyridine
  • A 85380
  • Azetidines
  • Fluorine Radioisotopes
  • Radioactive Tracers
  • Receptors, Nicotinic