Exercise training improves cardiac function postinfarction: special emphasis on recent controversies on na+/ca2+ exchanger

Exerc Sport Sci Rev. 2004 Jul;32(3):83-9. doi: 10.1097/00003677-200407000-00002.

Abstract

Exercise training instituted after myocardial infarction improves many steps involved in cardiac excitation-contraction coupling. Focusing on Na/Caexchange, current controversies regarding whether it mediates Cainflux during an action potential, whether it is increased or decreased in disease models, whether protein kinase A alters its activity, and whether exercise training affects its function are reviewed. Finally, a novel target for exercise training in the heart is suggested.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Calcium / pharmacology
  • Cell Size / drug effects
  • Cyclic AMP-Dependent Protein Kinases / metabolism
  • Dose-Response Relationship, Drug
  • Exercise / physiology*
  • Humans
  • Myocardial Infarction / metabolism
  • Myocardial Infarction / physiopathology*
  • Myocytes, Cardiac / cytology
  • Myocytes, Cardiac / drug effects
  • Myocytes, Cardiac / physiology
  • Physical Conditioning, Animal / physiology
  • Rats
  • Sodium-Calcium Exchanger / metabolism*

Substances

  • Sodium-Calcium Exchanger
  • Cyclic AMP-Dependent Protein Kinases
  • Calcium