Physiology: does gut hormone PYY3-36 decrease food intake in rodents?

Nature. 2004 Jul 8;430(6996):1 p following 165; discussion 2 p following 165. doi: 10.1038/nature02665.

Abstract

Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36.

Publication types

  • Comment

MeSH terms

  • Animals
  • Animals, Inbred Strains
  • Appetite / drug effects
  • Appetite / physiology
  • Appetite Depressants / pharmacology*
  • Appetite Depressants / therapeutic use
  • Appetite Regulation / drug effects*
  • Behavior, Animal / drug effects
  • Body Weight / drug effects
  • Environment
  • Feeding Behavior / drug effects*
  • Humans
  • Meta-Analysis as Topic
  • Mice
  • Obesity / drug therapy
  • Peptide Fragments
  • Peptide YY / administration & dosage
  • Peptide YY / blood
  • Peptide YY / pharmacology*
  • Peptide YY / therapeutic use
  • Rats
  • Reproducibility of Results
  • Stress, Physiological / complications
  • Stress, Physiological / physiopathology

Substances

  • Appetite Depressants
  • Peptide Fragments
  • Peptide YY
  • peptide YY (3-36)