Cell adhesion receptors, tyrosine kinases and actin modulators: a complex three-way circuitry

V G Brunton; I R J MacPherson; M C Frame

doi:10.1016/j.bbamcr.2004.04.010

Cell adhesion receptors, tyrosine kinases and actin modulators: a complex three-way circuitry

Biochim Biophys Acta. 2004 Jul 5;1692(2-3):121-44. doi: 10.1016/j.bbamcr.2004.04.010.

Authors

V G Brunton¹, I R J MacPherson, M C Frame

Affiliation

¹ The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD. [email protected]

PMID: 15246683
DOI: 10.1016/j.bbamcr.2004.04.010

Abstract

The interaction of cells with surrounding matrix and neighbouring cells governs many aspects of cell behaviour. Aside from transmitting signals from the external environment, adhesion receptors also receive signals from the cell interior. Here we review the interrelationship between adhesion receptors, tyrosine kinases (both growth factor receptor and non-receptor) and modulators of the actin cytoskeletal network. Deregulation of many aspects of these signalling pathways in cancer highlights the need for a better understanding of the complexities involved.

Publication types

Review

MeSH terms

Actins / metabolism*
Adherens Junctions / metabolism*
Animals
Binding Sites
Cadherins / metabolism
Cytoskeleton / metabolism
Focal Adhesion Kinase 1
Focal Adhesion Protein-Tyrosine Kinases
Humans
Integrins / metabolism*
Neoplasms / metabolism*
Protein-Tyrosine Kinases / metabolism
p120 GTPase Activating Protein / metabolism
src-Family Kinases / metabolism*

Substances

Actins
Cadherins
Integrins
p120 GTPase Activating Protein
Protein-Tyrosine Kinases
Focal Adhesion Kinase 1
Focal Adhesion Protein-Tyrosine Kinases
PTK2 protein, human
src-Family Kinases