A role for Streptococcus pneumoniae in virus-associated pneumonia

Shabir A Madhi; Keith P Klugman; Vaccine Trialist Group

doi:10.1038/nm1077

A role for Streptococcus pneumoniae in virus-associated pneumonia

Nat Med. 2004 Aug;10(8):811-3. doi: 10.1038/nm1077. Epub 2004 Jul 11.

Authors

Shabir A Madhi¹, Keith P Klugman; Vaccine Trialist Group

Affiliation

¹ University of the Witwatersrand/Medical Research Council/National Institute for Communicable Diseases Respiratory and Meningeal Pathogens Research Unit, Atlanta 30332, USA.

PMID: 15247911
PMCID: PMC7095883
DOI: 10.1038/nm1077

Abstract

Here we show, in a double-blind, randomized, placebo-controlled trial in 37,107 fully immunized infants in Soweto, South Africa, that a 9-valent pneumococcal conjugate vaccine, PncCV, prevents 31% (95% confidence interval = 15-43%) of pneumonias associated with any of seven respiratory viruses in children in hospital. These data suggest that the pneumococcus has a major role in the development of pneumonia associated with these viruses and that viruses contribute to the pathogenesis of bacterial pneumonia.

Publication types

Clinical Trial
Comparative Study
Randomized Controlled Trial

MeSH terms

Double-Blind Method
HIV Infections / complications*
Haemophilus Vaccines
Humans
Infant
Pneumococcal Vaccines / immunology*
Pneumonia, Viral / complications
Pneumonia, Viral / etiology*
Pneumonia, Viral / immunology
Respiratory Syncytial Viruses / immunology*
South Africa
Streptococcus pneumoniae / immunology*
Streptococcus pneumoniae / isolation & purification
Vaccines, Conjugate / immunology

Substances

Haemophilus Vaccines
Pneumococcal Vaccines
Vaccines, Conjugate