Abstract
Comparative investigation of immunoglobulin (Ig) heavy chain gene rearrangements and DNA sequence analyses of a primary lymphoma of the CNS (PCNSL) and its recurrence revealed that both tumors used the same Ig gene segment. In addition to shared somatic mutations, the primary and the recurrent PCNSLs harbored somatic mutations unique to each tumor. Clonal evolution rather than subclone selection appears to underlie the development of tumor recurrence in this case.
Publication types
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Case Reports
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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B-Lymphocytes / pathology*
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Base Sequence
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Breast Neoplasms / surgery
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Clone Cells / pathology*
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Combined Modality Therapy
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Cytarabine / administration & dosage
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DNA, Neoplasm / genetics
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Embryonal Carcinoma Stem Cells
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Female
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Gene Rearrangement, B-Lymphocyte, Heavy Chain
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Genes, Immunoglobulin
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Germinal Center / pathology
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Humans
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Lymphoma, Large B-Cell, Diffuse / drug therapy
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Lymphoma, Large B-Cell, Diffuse / pathology*
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Lymphoma, Large B-Cell, Diffuse / surgery
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Magnetic Resonance Imaging
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Methotrexate / administration & dosage
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Molecular Sequence Data
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Neoplasm Recurrence, Local / drug therapy
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Neoplasm Recurrence, Local / pathology*
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Neoplasms, Second Primary / surgery
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Neoplastic Stem Cells / pathology*
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Parietal Lobe / pathology
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Remission Induction
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Sequence Alignment
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Sequence Homology, Nucleic Acid
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Supratentorial Neoplasms / drug therapy
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Supratentorial Neoplasms / pathology*
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Supratentorial Neoplasms / surgery
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Temporal Lobe / pathology*
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Temporal Lobe / surgery
Substances
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DNA, Neoplasm
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Cytarabine
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Methotrexate