Abstract
The metabolic changes in the deep gray matter (GM) nuclei, thalamus, and basal ganglia of patients with relapsing-remitting multiple sclerosis were investigated with quantitative, multivoxel, three-dimensional proton MR spectroscopy. This technique facilitated the study of several bilateral structures in a single session at sub-cubic centimeter spatial resolution. Compared with 9 matched control subjects, the deep GM nuclei of 11 patients showed 7% lower N-acetylaspartate and 14% higher choline levels (p = 0.02 for both).
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aspartic Acid / analogs & derivatives*
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Aspartic Acid / analysis
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Basal Ganglia / chemistry
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Basal Ganglia / pathology*
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Choline / analysis
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Creatine / analysis
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Female
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Humans
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Imaging, Three-Dimensional*
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Multiple Sclerosis, Relapsing-Remitting / metabolism
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Multiple Sclerosis, Relapsing-Remitting / pathology*
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Nuclear Magnetic Resonance, Biomolecular / methods*
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Thalamic Nuclei / chemistry
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Thalamic Nuclei / pathology*
Substances
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Aspartic Acid
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N-acetylaspartate
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Creatine
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Choline