The Goodeniaceae family contributes some of the more spectacular wildflowers found on the Australian continent. The bright and vibrant colours that characterise members of the family has attracted much horticultural interest. A number of species have traditionally been used for medicinal purposes by indigenous communities, and the phytochemistry of some has been investigated. These aspects are considered in this review to determine correspondence between the reputed medicinal effects and the bioactivity of the secondary metabolites produced.