2(S)-Amino-3-[1H-imidazol-4(5)-yl]propyl cyclohexylmethyl ether dihydrochloride and 2(S)-amino-3-[1H-imidazol-4(5)-yl]propyl 4-bromobenzyl ether dihydrochloride

J T Kovalainen; E Wegelius; J A Christiaans; J Huuskonen; J Gynther

doi:10.1107/S0108270100005291

2(S)-Amino-3-[1H-imidazol-4(5)-yl]propyl cyclohexylmethyl ether dihydrochloride and 2(S)-amino-3-[1H-imidazol-4(5)-yl]propyl 4-bromobenzyl ether dihydrochloride

Acta Crystallogr C. 2000 May 15;56(Pt 5):E216-7. doi: 10.1107/S0108270100005291. Epub 2000 May 15.

Authors

J T Kovalainen¹, E Wegelius, J A Christiaans, J Huuskonen, J Gynther

Affiliation

¹ Department of Pharmaceutical Chemistry, University of Kuopio, PO Box 1627, FIN-70211 Kuopio, Finland.

PMID: 15263158
DOI: 10.1107/S0108270100005291

Abstract

(Cyclohexylmethyloxymethyl)(1H-imidazol-4-iomethyl)-(S)-ammonium dichloride, C(13)H(25)N(3)O(+).2Cl(-), and (4-bromobenzyl)(1H-imidazol-4-iomethyl)-(S)-ammonium dichloride, C(13)H(18)BrN(3)O(+).2Cl(-), are model compounds with different biological activities for evaluation of the histamine H3-receptor activation mechanism. Both title compounds occur in almost similar extended conformations.