Abstract
We collected 6 case-reports of symptomatric non removable low grade fibrillary astrocytoma of adults treated with a procarbazine-CCNU-vincristine chemotherapy regimen. All patients had drug-resistant epilepsy but brain imaging was stable. Total gross resection was rejected because of Volume or tumor location. After 4 to 7 cycles of chemotherapy, 2 patients had partial response and one minor response on brain MRI. All of them were seizure-free. Progression free survival was not reached at 5 Years. Up-front chemotherapy for low-grade astrocytomas may be useful and has to be prospectively evaluated.
Publication types
-
Case Reports
-
English Abstract
MeSH terms
-
Adult
-
Antineoplastic Agents, Phytogenic / administration & dosage
-
Antineoplastic Combined Chemotherapy Protocols / adverse effects
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
-
Astrocytoma / complications
-
Astrocytoma / drug therapy*
-
Astrocytoma / pathology
-
Brain Neoplasms / complications
-
Brain Neoplasms / drug therapy*
-
Brain Neoplasms / pathology
-
Disease Progression
-
Drug Resistance
-
Epilepsy / complications
-
Epilepsy / drug therapy
-
Female
-
Humans
-
Lomustine / administration & dosage
-
Magnetic Resonance Imaging
-
Male
-
Middle Aged
-
Procarbazine / administration & dosage
-
Procarbazine / adverse effects
-
Vincristine / administration & dosage
Substances
-
Antineoplastic Agents, Phytogenic
-
Procarbazine
-
Vincristine
-
Lomustine