Objective: This study focuses on a case report on a patient with renal carcinoma who developed metastases at unusual sites. We also reviewed the literature, including the theories proposed by various authors on the possible etiology of these odd localizations.
Case report: A 48-year-old patient underwent conservative surgery for renal carcinoma (papillary adenocarcinoma). Twenty-two months later, he developed mediastinal metastases and underwent immunotherapy; two years after that he had metastases to unusual sites such as the urethra and the prostate. The mechanisms responsible for metastases to these unusual sites are not entirely clear yet. We feel it is important to note the highly aggressive and multifocal nature of papillary adenocarcinoma, and the need to perform closer follow-up on these patients, particularly if nephron-sparing surgery has been performed.