First introduced a decade ago, computerized tomography (CT) colonography (virtual colonoscopy) is emerging as an important radiologic investigation for colorectal neoplasia, with diagnostic performance likely exceeding barium enema and comparable with optical colonoscopy. Employing state-of-the-art multislice technology, CT colonography allows a complete examination of the colon and surrounding organs in less than 30 seconds. This article reviews current techniques, indications, comparison with existing technologies, and diagnostic performance. Although already widely disseminated, important future developments, such as prepless bowel cleansing (laxative free) and computer-aided diagnosis, may establish CT colonography as the preferred first-line, whole-colon investigation.