Hydrochlorothiazide induced hepato-cholestatic liver injury

Age Ageing. 2004 Sep;33(5):509-10. doi: 10.1093/ageing/afh148. Epub 2004 Jul 22.

Abstract

Hydrochlorothiazide and other thiazide-like diuretics are considered as a first-line drug for initial therapy in uncomplicated arterial hypertension [1]. There are several reports [2-6] of thiazide-induced cholecystitis, but here we report a case of serious hepatotoxicity associated with hydrochlorothiazide treatment.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antihypertensive Agents / therapeutic use
  • Antihypertensive Agents / toxicity*
  • Chemical and Drug Induced Liver Injury / etiology*
  • Cholestasis, Intrahepatic / chemically induced*
  • Cholestasis, Intrahepatic / diagnosis
  • Diagnosis, Differential
  • Female
  • Humans
  • Hydrochlorothiazide / therapeutic use
  • Hydrochlorothiazide / toxicity*
  • Hypertension / drug therapy*
  • Liver Function Tests

Substances

  • Antihypertensive Agents
  • Hydrochlorothiazide