Abstract
The role of nitric oxide in group B Streptococcus (GBS) infection was evaluated by inhibiting its production with aminoguanidine (AG). AG-treated mice displayed higher mortality rates and more frequent and severe arthritis than controls. Worsening of arthritis correlated with a higher number of GBS cells in the joints and local interleukin-1 beta production.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Outbred Strains
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Arthritis, Infectious / drug therapy
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Arthritis, Infectious / microbiology
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Arthritis, Infectious / mortality
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Arthritis, Infectious / physiopathology*
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Enzyme Inhibitors / administration & dosage
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Enzyme Inhibitors / pharmacology*
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Female
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Guanidines / administration & dosage
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Guanidines / pharmacology*
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Humans
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Male
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Mice
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Nitric Oxide / physiology*
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Nitric Oxide / urine
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Nitric Oxide Synthase / antagonists & inhibitors*
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Nitric Oxide Synthase Type II
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Sepsis / drug therapy
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Sepsis / mortality
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Sepsis / physiopathology*
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Severity of Illness Index
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Streptococcal Infections / drug therapy
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Streptococcal Infections / microbiology
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Streptococcal Infections / mortality
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Streptococcal Infections / physiopathology*
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Streptococcus agalactiae / pathogenicity*
Substances
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Enzyme Inhibitors
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Guanidines
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Nitric Oxide
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NOS2 protein, human
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type II
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Nos2 protein, mouse
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pimagedine