Peroxisome proliferator-activated receptor gamma; Its role in atherosclerosis and restenosis

Cardiovasc Radiat Med. 2004 Jan-Mar;5(1):44-8. doi: 10.1016/j.carrad.2004.04.001.

Abstract

Cellular proliferation and migration are fundamental processes that contribute to the injury response in major blood vessels. The resultant pathologies are atherosclerosis and restenosis. As we begin to understand the cellular changes associated with vascular injury, it is critical to determine whether the inhibition of growth and movement of cells in the vasculature could serve as a novel therapeutic strategy to prevent atherosclerosis and restenosis.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Biomarkers / blood
  • Cell Proliferation / drug effects
  • Cells, Cultured
  • Coronary Artery Disease / physiopathology*
  • Coronary Artery Disease / prevention & control
  • Coronary Restenosis / prevention & control*
  • Coronary Stenosis / physiopathology*
  • Coronary Stenosis / prevention & control
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Muscle, Smooth, Vascular / cytology
  • Muscle, Smooth, Vascular / drug effects*
  • Peroxisome Proliferator-Activated Receptors / antagonists & inhibitors*
  • Peroxisome Proliferator-Activated Receptors / metabolism
  • Risk Assessment
  • Sensitivity and Specificity

Substances

  • Biomarkers
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Peroxisome Proliferator-Activated Receptors