Palladium-catalyzed enantioselective ring opening of oxabicyclic alkenes with organozinc halides

Org Lett. 2004 Aug 5;6(16):2833-5. doi: 10.1021/ol048816i.

Abstract

Palladium-catalyzed asymmetric ring opening of oxabenzonorbornadienes with readily available organozinc halides under mild conditions in the presence of (S)-Pr(i)-PHOX produces the corresponding 1,2-dihydronaphth-1-ols in good yield and high enantioselectivity. [reaction: see text]