Abstract
Four clonally related Escherichia coli strains were isolated successively from bile duct of a girl suffering from sclerosing cholangitis. One of them, selected after an imipenem-containing regimen, was resistant to carbapenems and to broad-spectrum cephalosporins due to a plasmid-mediated cephalosporinase, CMY-2, and the lack of outer membrane proteins OmpF and OmpC.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Base Sequence
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Child
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DNA Primers
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Drug Resistance, Bacterial*
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Escherichia coli / drug effects*
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Escherichia coli / genetics
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Escherichia coli / isolation & purification
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Escherichia coli Infections / diagnosis
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Escherichia coli Infections / drug therapy
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Female
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Humans
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Imipenem / pharmacology*
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Microbial Sensitivity Tests / methods
Substances
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Anti-Bacterial Agents
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DNA Primers
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Imipenem