[Ca2+] and [Na+] in rat ventricular myocytes showing negative and positive force frequency relationships

J E Frampton; S M Harrison; C H Orchard

doi:10.1007/978-1-4615-3362-7_29

[Ca2+] and [Na+] in rat ventricular myocytes showing negative and positive force frequency relationships

Adv Exp Med Biol. 1992:311:335-6. doi: 10.1007/978-1-4615-3362-7_29.

Authors

J E Frampton¹, S M Harrison, C H Orchard

Affiliation

¹ Department of Physiology, University of Leeds, U.K.

PMID: 1529764
DOI: 10.1007/978-1-4615-3362-7_29

Abstract

Ventricular cells that show a positive force-frequency relationship show graded changes of intracellular [Ca2+] (Cai), [Na+] (Nai) and sarcoplasmic reticulum Ca2+ content with changes of stimulation frequency. Cells that show a negative force-frequency relationship show smaller changes of Nai and no change in the Ca2+ load of the sarcoplasmic reticulum as stimulation frequency is changed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Calcium / metabolism*
Cells, Cultured
Electric Stimulation
Heart / physiology*
Heart Ventricles
Myocardial Contraction / physiology*
Rats
Sarcoplasmic Reticulum / metabolism
Sodium / metabolism*

Substances

Sodium
Calcium