A mechanical basis for chromosome function

Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12592-7. doi: 10.1073/pnas.0402724101. Epub 2004 Aug 6.

Abstract

We propose that chromosome function is governed by internal mechanical forces generated by programmed tendencies for expansion of the DNA/chromatin fiber against constraining features.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromatin / chemistry
  • Chromatin / metabolism
  • Chromatin / ultrastructure
  • Chromosomes / chemistry*
  • Chromosomes / metabolism*
  • Chromosomes / ultrastructure
  • DNA, Plant / chemistry
  • DNA, Plant / metabolism
  • DNA, Plant / ultrastructure
  • Humans
  • Meiosis
  • Mitosis
  • Models, Biological
  • Nucleic Acid Conformation
  • Stress, Mechanical
  • Time Factors

Substances

  • Chromatin
  • DNA, Plant