Parkinson's disease-like presentation of multiple system atrophy with poor response to STN stimulation: a clinicopathological case report

Mov Disord. 2004 Aug;19(8):973-7. doi: 10.1002/mds.20108.

Abstract

We report on a clinicopathological case of multiple system atrophy with good response to levodopa and subsequent development of motor complications. Because the subject complied with all the inclusion criteria (Core Assessment Program for Surgical Interventional Therapies in Parkinson's Disease), bilateral subthalamic nucleus deep brain stimulation electrodes were implanted.

Publication types

  • Case Reports

MeSH terms

  • Antiparkinson Agents / therapeutic use
  • Benzamides / pharmacokinetics
  • Dopamine Antagonists / pharmacokinetics
  • Electric Stimulation Therapy*
  • Follow-Up Studies
  • Humans
  • Immunohistochemistry / methods
  • Levodopa / therapeutic use
  • Male
  • Middle Aged
  • Multiple System Atrophy / complications*
  • Multiple System Atrophy / diagnostic imaging
  • Nerve Tissue Proteins / metabolism
  • Neurons / metabolism
  • Neurons / pathology
  • Parkinson Disease / diagnostic imaging
  • Parkinson Disease / etiology
  • Parkinson Disease / therapy*
  • Pyrrolidines / pharmacokinetics
  • Retrospective Studies
  • Staining and Labeling
  • Subthalamic Nucleus / diagnostic imaging
  • Subthalamic Nucleus / metabolism
  • Subthalamic Nucleus / pathology
  • Subthalamic Nucleus / radiation effects*
  • Synucleins
  • Tomography, Emission-Computed, Single-Photon / methods

Substances

  • Antiparkinson Agents
  • Benzamides
  • Dopamine Antagonists
  • Nerve Tissue Proteins
  • Pyrrolidines
  • Synucleins
  • Levodopa
  • 3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide