Description of a new HLA-DRB1 allele, DRB1*1150

Tissue Antigens. 2004 Sep;64(3):298-9. doi: 10.1111/j.1399-0039.2004.00289.x.

Abstract

We report the identification of a novel HLA-DRB1*11 using sequence-based typing. This new allele, officially named DRB1*1150, was detected while performing HLA-DRB1 high-resolution typing of a candidate for bone marrow transplantation. DRB1*1150 is identical to DRB1*1143 except at nucleotides 200 and 227, where a T is substituted by a C and a T by an A, respectively. These differences give rise to two amino acid substitutions at codons 38 (Val-->Ala) and 47 (Phe-->Tyr).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution / genetics
  • Base Sequence
  • Bone Marrow Transplantation
  • Exons
  • HLA-DR Antigens / genetics*
  • HLA-DRB1 Chains
  • Humans
  • Male
  • Molecular Sequence Data

Substances

  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • HLA-DRB1*11:50 antigen

Associated data

  • GENBANK/AJ627279