Molecular cloning and characterization of catechol 2,3-dioxygenases from biphenyl/polychlorinated biphenyls-degrading bacteria

Biochem Biophys Res Commun. 1992 Sep 16;187(2):609-14. doi: 10.1016/0006-291x(92)91238-l.

Abstract

Catechol 2,3-dioxygenases were cloned from Alcaligenes sp. KF711, Pseudomonas putida KF715, and Achromobacter xylosoxidans KF701 which are biphenyl/polychlorinated biphenyls-degrading bacteria. All of the cloned enzymes were purified by preparative polyacrylamide gel electrophoresis (PAGE). The purified catechol 2,3-dioxygenases were significantly different from one another in ring-fission activities to catechol and its derivatives. The catechol 2,3-dioxygenase from Alcaligenes sp. KF711 exhibited higher ring-fission activity to 4-chlorocatechol than those from P. putida KF715 and A. xylosoxidans KF701. In electrophoretic mobilities, the three enzymes were different from one another on nondenaturing PAGE but the same on SDS-PAGE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcaligenes / enzymology*
  • Alcaligenes / genetics
  • Biphenyl Compounds / metabolism*
  • Catechol 2,3-Dioxygenase
  • Cloning, Molecular*
  • DNA, Bacterial / genetics
  • DNA, Recombinant
  • Dioxygenases*
  • Electrophoresis, Polyacrylamide Gel
  • Oxygenases / genetics*
  • Oxygenases / metabolism
  • Polychlorinated Biphenyls / metabolism*
  • Pseudomonas putida / enzymology*
  • Pseudomonas putida / genetics
  • Restriction Mapping

Substances

  • Biphenyl Compounds
  • DNA, Bacterial
  • DNA, Recombinant
  • Polychlorinated Biphenyls
  • Oxygenases
  • Dioxygenases
  • Catechol 2,3-Dioxygenase