Abstract
Sickle cell genotype prevalence was 26% in a malaria-holoendemic lowland area compared with 3% in a highland area of Kenya. The prevalence of glucose-6-phosphate dehydrogenase deficiency was 7% and 1% in holoendemic lowland and highland areas, respectively. Lack of protective polymorphisms may contribute to morbidity and mortality during outbreaks of malaria in the highlands.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adult
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Aged
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Altitude
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Child
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Child, Preschool
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Endemic Diseases
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Glucosephosphate Dehydrogenase Deficiency / epidemiology*
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Glucosephosphate Dehydrogenase Deficiency / genetics
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Hemoglobin, Sickle / genetics
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Humans
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Infant
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Infant, Newborn
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Kenya / epidemiology
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Malaria, Falciparum / epidemiology*
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Malaria, Falciparum / genetics
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Middle Aged
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Polymorphism, Genetic
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Prevalence
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Residence Characteristics
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Sickle Cell Trait / epidemiology*
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Sickle Cell Trait / genetics
Substances
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Hemoglobin, Sickle
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hemoglobin AS