Hedgehog signaling: iguana debuts as a nuclear gatekeeper

Steven A Vokes; Andrew P McMahon

doi:10.1016/j.cub.2004.08.015

Hedgehog signaling: iguana debuts as a nuclear gatekeeper

Curr Biol. 2004 Aug 24;14(16):R668-70. doi: 10.1016/j.cub.2004.08.015.

Authors

Steven A Vokes¹, Andrew P McMahon

Affiliation

¹ Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA. [email protected]

PMID: 15324687
DOI: 10.1016/j.cub.2004.08.015

Abstract

The intracellular pathway that controls the cytoplasmic versus nuclear distribution of Gli transcriptional regulators in response to Hedgehog signaling remains poorly understood. Iguana appears to play a role in regulating this process independently of Hedgehog signaling.

Publication types

Review

MeSH terms

Animals
Carrier Proteins / genetics
Carrier Proteins / metabolism*
Carrier Proteins / physiology*
Cell Nucleus / physiology
Cytoplasm / physiology
Hedgehog Proteins
Models, Genetic
Oncogene Proteins / metabolism
Oncogene Proteins / physiology*
Protein Transport
Signal Transduction / physiology*
Trans-Activators / metabolism
Trans-Activators / physiology*
Transcription Factors / metabolism
Transcription Factors / physiology*
Zinc Finger Protein GLI1

Substances

Carrier Proteins
Dzip1 protein, zebrafish
Hedgehog Proteins
Oncogene Proteins
Trans-Activators
Transcription Factors
Zinc Finger Protein GLI1