Identification of a potent and rapidly reversible inhibitor of the 20S-proteasome

Bioorg Med Chem Lett. 2004 Sep 20;14(18):4701-4. doi: 10.1016/j.bmcl.2004.06.084.

Abstract

Synthesis and in vitro characterization of novel, lactam boronic acid based, selective, and rapidly reversible inhibitor 14 of the 20S-proteasome is presented.

Publication types

  • Comparative Study

MeSH terms

  • Boronic Acids / chemical synthesis*
  • Boronic Acids / chemistry
  • Bortezomib
  • Humans
  • Protease Inhibitors / chemical synthesis
  • Protease Inhibitors / chemistry*
  • Proteasome Endopeptidase Complex / chemistry
  • Proteasome Inhibitors*
  • Pyrazines / chemical synthesis*
  • Pyrazines / chemistry
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Boronic Acids
  • Protease Inhibitors
  • Proteasome Inhibitors
  • Pyrazines
  • Bortezomib
  • Proteasome Endopeptidase Complex