Abstract
In vivo antimalarial drug efficacy studies of uncomplicated Plasmodium falciparum malaria at an isolated site in the Amazon basin of Peru bordering Brazil and Colombia showed >50% RII/RIII resistance to sulfadoxine-pyrimethamine but no evidence of resistance to mefloquine.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adolescent
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Adult
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Animals
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Antimalarials / administration & dosage
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Antimalarials / therapeutic use*
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Child
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Child, Preschool
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Drug Combinations
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Drug Resistance
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Drug Therapy, Combination
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Female
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Humans
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Infant
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Malaria, Falciparum / drug therapy*
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Male
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Mefloquine / administration & dosage
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Mefloquine / therapeutic use*
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Middle Aged
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Peru
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Plasmodium falciparum / drug effects*
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Pyrimethamine / administration & dosage
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Pyrimethamine / therapeutic use*
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Sulfadoxine / administration & dosage
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Sulfadoxine / therapeutic use*
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Treatment Outcome
Substances
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Antimalarials
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Drug Combinations
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fanasil, pyrimethamine drug combination
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Sulfadoxine
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Mefloquine
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Pyrimethamine