Abstract
This study investigated whether neuraminidase (Neu) affects LFA-1 mRNA expression in spleen cells and whether somatostatin (SOM) and substance P (SP) treatment induce changes in the Neu mRNA expression level in spleen cells. Neu treatments down-regulated the LFA-1 mRNA levels after culturing for 2 h. SOM increased the Neu mRNA level slightly after 24-h culture and strongly after 48-h culture. These results suggest that prolonged exposure to SOM may regulate the Neu activation pathway, which in turn impairs the regulation of LFA-1 expression.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Gene Expression Regulation / drug effects
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Gene Expression Regulation / physiology
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Lymphocyte Function-Associated Antigen-1 / biosynthesis*
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Lymphocyte Function-Associated Antigen-1 / genetics
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Mice
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Mice, Inbred C3H
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Neuraminidase / biosynthesis*
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Neuraminidase / genetics
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
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Somatostatin / pharmacology*
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Spleen / drug effects*
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Spleen / metabolism
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Spleen / physiology*
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Substance P / pharmacology
Substances
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Lymphocyte Function-Associated Antigen-1
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RNA, Messenger
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Substance P
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Somatostatin
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Neuraminidase