Synthesis, structural properties and insulin-enhancing potential of bis(quercetinato)oxovanadium(IV) conjugate

Bioorg Med Chem Lett. 2004 Oct 4;14(19):4961-5. doi: 10.1016/j.bmcl.2004.07.020.

Abstract

An oxovanadium complex of quercetin (2), exhibits highly potent insulin-enhancing activity in streptozotocin-induced diabetic mice. It also mimics mitogenic potential of insulin as evaluated by [H(3)]thymidine uptake assay making an effective, orally active insulin-enhancing agent for the treatment of both type 1 and type 2 diabetes without any noticeable toxic effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Hypoglycemic Agents / chemical synthesis*
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / pharmacology
  • Magnetics
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mitogens / pharmacology
  • Pyrones / pharmacology
  • Quercetin / chemical synthesis*
  • Quercetin / pharmacology
  • Vanadates / chemical synthesis*
  • Vanadates / pharmacology

Substances

  • Hypoglycemic Agents
  • Mitogens
  • Pyrones
  • oxovanadium IV
  • bis(maltolato)oxovanadium(IV)
  • Vanadates
  • Quercetin