Abstract
A Japanese child born to an HBeAg-positive carrier mother received anti-HBs immunoglobulins and a plasma-derived HBs vaccine with a poor anti-HBs-antibody response. The child, who is now 3 years old, is presently suffering from chronic hepatitis with unusual serological findings that are positive for HBsAg, anti-HBs and HBeAg, since being infected with a measles virus at 12 months of age. The nucleotide sequences of the S region of HBV DNA obtained from the patient, the mother and an HBeAg-positive brother were completely identical except for one nucleotide at position 587 (mother and brother: guanosine, patient: adenosine), giving an amino acid change: Gly - greater than Arg at position 145 of the major HBs protein.
MeSH terms
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Amino Acid Sequence
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Arginine*
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Base Sequence
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Carrier State
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DNA, Viral / genetics
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DNA, Viral / isolation & purification
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Female
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Genetic Variation*
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Glycine*
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Hepatitis B / immunology*
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Hepatitis B Surface Antigens / analysis
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Hepatitis B Surface Antigens / genetics*
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Hepatitis B Vaccines
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Hepatitis B e Antigens / analysis
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Hepatitis B virus / genetics
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Hepatitis B virus / immunology*
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Humans
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Immunization, Passive*
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Infant, Newborn
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Male
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Molecular Sequence Data
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Polymerase Chain Reaction / methods
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Vaccines, Synthetic / administration & dosage
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Viral Hepatitis Vaccines / administration & dosage
Substances
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DNA, Viral
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Hepatitis B Surface Antigens
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Hepatitis B Vaccines
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Hepatitis B e Antigens
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Vaccines, Synthetic
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Viral Hepatitis Vaccines
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Arginine
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Glycine