Blood interactions with plasticized poly(vinyl chloride): relevance of plasticizer selection

H Q Yin; X B Zhao; J M Courtney; C R Blass; R H West; G D Lowe

doi:10.1023/a:1008912213420

Blood interactions with plasticized poly(vinyl chloride): relevance of plasticizer selection

J Mater Sci Mater Med. 1999 Sep;10(9):527-31. doi: 10.1023/a:1008912213420.

Authors

H Q Yin¹, X B Zhao, J M Courtney, C R Blass, R H West, G D Lowe

Affiliation

¹ Bioengineering Unit, University of Strathclyde, Glasgow, UK.

PMID: 15348103
DOI: 10.1023/a:1008912213420

Abstract

An investigation has been made of blood interactions with plasticized poly(vinyl chloride) (PVC) biomaterials in tubular form, taking into account the influence on the blood response of the polymer, antithrombotic agent, blood condition and test procedure. In vitro and ex vivo procedures were used to achieve a comparison between PVC plasticized with di- (2-ethylhexyl)phthalate (DEHP) and with tri-(2-ethylhexyl)trimellitate (TEHTM). The blood response was monitored in terms of the measurement of fibrinogen adsorption capacity, thrombin-antithrombin III complex (TAT) and the complement component C3a. Surface characterization of the polymers was performed by X-ray photoelectron spectroscopy (XPS). The data obtained indicate that in comparison with DEHP-PVC, there is a higher reactivity for TEHTM-PVC, which correlates with the plasticizer distribution at the polymer surface.